国产精品99一区二区三_免费中文日韩_国产在线精品一区二区_日本成人手机在线

Hong Kong scientists discover deadly brain cancer mutation route

Source: Xinhua| 2018-12-03 22:09:36|Editor: Li Xia
Video PlayerClose

HONG KONG, Dec. 3 (Xinhua) -- The mutational mechanism of a rare and deadly brain cancer has been uncovered by scientists from the Hong Kong University of Science and Technology, providing new therapeutic lead to the disease.

Starting off at nerve cells around the spine and brain, lower-grade glioma (LGG) is the early form of sGBM -- one of the deadliest brain cancers. While sGBM can be treated with surgery or an oral chemotherapy drug, most of these malign tumors would mutate and return with mortality rate reaching almost 100 percent.

In their latest study made public on Monday, the team led by Wang Jiguang, assistant professor at the university's Division of Life Science and Department of Chemical and Biological Engineering, analyzed and integrated the genomic data of 188 sGBM patients, including newly collected samples from Chinese mainland and South Korean patients.

The study found that about 14 percent of the sampled sGBM patients displayed mutations in this gene.

Taking reference from this discovery, the university's collaborators, Jiang Tao and his team from Beijing Neurosurgical Institute and Beijing Tiantan Hospital, identified a drug molecule named PLB-1001 that can reach the tumors in the brain.

The molecule shows remarkable potency in selectively targeting sGBM tumors and those displaying further gene mutations.

The clinical trial of PLB-1001 on 18 recurrent patients at late cancer stage returned with a partial positive response in two patients.

After being prescribed a daily dosage ranging from 50 to 300 mg at Beijing Tiantan Hospital, the two patients experienced significant tumor shrinkage, with relieved symptoms and little side effects, lasting for more than 12 weeks.

The outcome of this clinical trial is significant in a sense that it furthers the knowledge about sGBM treatment, Wang said, adding that developing computational models on cancer evolution helps predict cancer cells' future behavior and prioritize treatment options.

Wang said more studies on PLB-1001 are needed to see if it can be used in conjunction with other drugs in achieving more persistent results.

The findings were published in scientific journal Cell on Nov. 29.

TOP STORIES
EDITOR’S CHOICE
MOST VIEWED
EXPLORE XINHUANET
010020070750000000000000011100001376484241
主站蜘蛛池模板: 赤壁市| 鲁山县| 青州市| 达日县| 华亭县| 桃园市| 嘉义县| 安远县| 津南区| 从江县| 漳浦县| 乐亭县| 宜春市| 平原县| 平乡县| 新兴县| 科技| 铁力市| 莒南县| 平顺县| 遂川县| 长葛市| 彭水| 江城| 嘉黎县| 贡觉县| 沙洋县| 平江县| 乐清市| 南昌市| 平谷区| 玉树县| 云霄县| 永善县| 西峡县| 任丘市| 山东省| 城固县| 郎溪县| 滨州市| 古丈县|