国产精品99一区二区三_免费中文日韩_国产在线精品一区二区_日本成人手机在线

British scientists identify kidney cancer's cellular origin

Source: Xinhua| 2018-08-10 03:01:48|Editor: Mu Xuequan
Video PlayerClose

WASHINGTON, Aug. 9 (Xinhua) -- British scientists revealed the precise identity of cancer cells of the most common childhood and adult kidney cancers, according to a study published on Thursday in the journal Science.

Researchers from the Wellcome Sanger Institute, the University of Cambridge, University of Newcastle and their collaborators showed that the cancer cells were versions of specific healthy cells from developing or adult kidneys.

This study could lead to the development of completely new methods of treating kidney cancers, which could persuade the cancerous cells to develop in specific ways into safer cells.

The most prevalent adult kidney cancer is renal cell carcinomas and the most prevalent childhood kidney cancer is Wilms' tumor.

Researchers investigated more than 72,000 individual kidney cells from healthy and cancerous tissue, comparing Wilms' tumour and renal cell carcinoma cells with normal cells from developing, children's, teen or adult kidneys.

Using a powerful technique called single cell RNA sequencing, they discovered that children's Wilms' cancer cells have the same characteristics as a specific normal developing kidney cell, indicating that these kidney cells failed to develop properly in the womb.

"Wilms' tumour cells have the same characteristics of a normal developing kidney cell, which may have got stuck during development," said Sam Behjati, leader of the study from the Wellcome Sanger Institute.

"This could lead to an entirely new model for treating childhood cancer, by manipulating the development state of the cells instead of trying to kill them with chemotherapy," said Behjati.

The researchers also discovered that the adult renal carcinoma cells are a version of a specific rare subtype of healthy adult kidney cell, called PT1.

They found that despite genetic differences, all the renal carcinoma cells studied had developed the same PT1 characteristics.

Those results could provide the basis of a new method for treating cancer by targeting this PT1 cell specifically.

Muzlifah Haniffa, a corresponding author on the paper from Newcastle University, said: "Using large-scale single cell RNA sequencing, we could precisely define the characteristics of kidney tumor cells for the first time, and compare them with healthy reference kidney cells from different development stages and ages."

"This approach will help towards understanding not only kidney cancer, but many other diseases that have their origin during development," said Haniffa.

TOP STORIES
EDITOR’S CHOICE
MOST VIEWED
EXPLORE XINHUANET
010020070750000000000000011105091373797111
主站蜘蛛池模板: 科技| 泌阳县| 繁昌县| 富平县| 双柏县| 河北省| 静海县| 昌平区| 哈巴河县| 海盐县| 岗巴县| 平昌县| 青浦区| 成武县| 长治县| 阳朔县| 涟水县| 荔浦县| 乐东| 苏尼特右旗| 凤山市| 古丈县| 晋中市| 金溪县| 云龙县| 城口县| 达日县| 略阳县| 天气| 成安县| 青浦区| 加查县| 峨边| 林周县| 新野县| 莆田市| 安徽省| 七台河市| 海兴县| 旬邑县| 嘉善县|