国产精品99一区二区三_免费中文日韩_国产在线精品一区二区_日本成人手机在线

Study links mutation that disrupts DNA's electrical signaling to colon cancer

Source: Xinhua| 2018-06-19 07:10:34|Editor: Chengcheng
Video PlayerClose

CHICAGO, June 18 (Xinhua) -- A single missing iron atom in a key DNA repair protein may be the root cause for the development of an aggressive, early-onset form of colon cancer, according to a study jointly conducted by the University of Michigan (UM) Life Sciences Institute, the California Institute of Technology and the University of Southern California.

The findings are published on June 18 in Nature Chemistry.

The research started when a professor identified an unusual genetic mutation from a family of patients with early-onset colon cancer. Through genetic analysis, the researchers determined that the mutation was affecting MUTYH.

"This is an essential DNA-repair enzyme," said David Sherman, research professor at UM's Life Sciences Institute. "It scans along the DNA and, if there is a mutation, it can sense the mutation, cut out the bad base and put in a new one.

In order to know how it scans, the researchers have characterized the protein biochemically, and discovered that the mutation, called C306W, affects a portion of the protein that normally helps hold a critical co-factor made up of a cluster of four iron and four sulfur atoms inside the protein. The mutation causes the iron-sulfur cluster to be degraded when exposed to oxygen, resulting in a cluster with only three iron atoms.

And with that one iron atom missing, the MUTYH protein can't do its job.

Latest research demonstrates that there is electrical signaling working in human versions of DNA repair proteins, and that interruptions to this process may be linked to cancer.

"This ability of DNA to transmit electrical signals is essentially how MUTYH detects where there's a lesion, by virtue of this cluster of iron and sulfur atoms," Sherman said.

Normally, the iron-sulfur cluster on the protein allows electrons to pass in and out of the MUTYH protein, enabling it to receive signals about damaged DNA. With one iron atom missing, however, the protein is no longer able to receive and interpret the electronic signals being transmitted along the DNA strand. And without that signaling, it cannot find and repair a damaged gene.

Moreover, as this one mutation to the gene that makes the MUTYH protein disables it from repairing damaged DNA, it leads to further mutations across the genome.

"This mutation essentially allows the human genome to develop multiple mutations in other cancer repressors: proteins that actually can control the onset of malignancy," Sherman said. Enditem

TOP STORIES
EDITOR’S CHOICE
MOST VIEWED
EXPLORE XINHUANET
010020070750000000000000011100001372635591
主站蜘蛛池模板: 城固县| 安泽县| 阜阳市| 佳木斯市| 天祝| 林西县| 康保县| 印江| 自贡市| 潜江市| 莱西市| 桐城市| 庄浪县| 济阳县| 乐都县| 平舆县| 泾源县| 大丰市| 南岸区| 石景山区| 德州市| 忻城县| 乌拉特前旗| 大丰市| 正镶白旗| 临武县| 蕉岭县| 聂拉木县| 教育| 迁安市| 承德市| 霍州市| 大姚县| 习水县| 武宣县| 凤城市| 张掖市| 简阳市| 洪泽县| 德昌县| 龙口市|