国产精品99一区二区三_免费中文日韩_国产在线精品一区二区_日本成人手机在线

Source of damaging inflammation after heart attack identified: study

Source: Xinhua| 2018-06-08 06:23:42|Editor: yan
Video PlayerClose

CHICAGO, June 7 (Xinhua) -- Researchers at Washington University School of Medicine in St. Louis have zeroed in on B cells that try to heal the injured heart following a heart attack but instead trigger inflammation that leads to even more damage.

The study is published June 7 in JCI Insight.

And they also found that an already approved drug, Pirfenidone, effectively tamps down such inflammation in mice, protecting the heart from the progressive damage that often occurs after a heart attack.

The researchers' immune studies of the heart still focus on other types of immune cells, including macrophages, T cell lymphocytes, neutrophils and monocytes. They first did not find any differences in the numbers of such immune cells in the injured hearts of mice that received pirfenidone versus those that didn't. But when they serendipitously measured B cells, they saw a huge difference.

"Our results showing B cells driving heart inflammation was quite unexpected," said first author Luigi Adamo, a clinical fellow in cardiology. "We didn' t know that B cells have a role in the type of heart damage we were studying until our data pushed us in that direction. We also found that there isn't just one type of B cell in the heart, but a whole family of different types that are closely related. And pirfenidone modulates these cells to have a protective effect on heart muscle after a heart attack."

When these cells were removed completely, not only was the heart not protected, the beneficial effect of the drug went away. So the B cells are not exclusively bad, the researchers said.

"The protective effects of pirfenidone hinge on the presence of B cells," Adamo said. "The drug may be working on other cells as well, perhaps directly or perhaps through the B cells. We're continuing to investigate the details."

Pirfenidone, a drug approved by the Food and Drug Administration to treat a lung condition called idiopathic pulmonary fibrosis, has long been considered safe. But it can have such side effects as nausea and vomiting.

Now that the researchers have identified B cell lymphocytes as the drug's target, they can begin investigating ways to make it better.

TOP STORIES
EDITOR’S CHOICE
MOST VIEWED
EXPLORE XINHUANET
010020070750000000000000011105521372383231
主站蜘蛛池模板: 白银市| 松桃| 家居| 阳谷县| 吉安市| 乌苏市| 宁夏| 博湖县| 宝清县| 商南县| 镇沅| 辛集市| 韩城市| 东明县| 二连浩特市| 平果县| 保靖县| 蒙山县| 宜川县| 长垣县| 汕头市| 岱山县| 临城县| 沙湾县| 神木县| 康乐县| 五常市| 安丘市| 尖扎县| 桐庐县| 藁城市| 平舆县| 宁乡县| 庄浪县| 石嘴山市| 阳信县| 镇赉县| 盐城市| 吉木萨尔县| 乌拉特后旗| 那曲县|